2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-120489
    A110
    		Activator
    A110 is the inhibitor for Cryptosporidium parvum inosine monophosphate dehydrogenase (CpIMPDH). A110 inhibits CpIMPDH in Toxoplasma gondii with IC50 of 18 nM. A110 exhibits pro-parasitic efficacy and cause parasitemia.
    A110
  • HY-19877
    GSK932121
    		Inhibitor
    GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies.
    GSK932121
  • HY-N7281
    Aphadilactone C
    		Inhibitor
    Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM.
    Aphadilactone C
  • HY-105569
    Amphotalide
    		Inhibitor
    Amphotalide is an anticonvulsant.
    Amphotalide
  • HY-161237
    Antitrypanosomal agent 20
    		Inhibitor
    Antitrypanosomal agent 20 (Compd 27) is an anti-trypanosomal, with an IC50 of 0.75 μM for T. b. brucei.
    Antitrypanosomal agent 20
  • HY-134914
    Fosmidomycin
    		Inhibitor
    Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model.
    Fosmidomycin
  • HY-N0281R
    Daphnetin (Standard)
    		Inhibitor
    Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research.
    Daphnetin (Standard)
  • HY-160633
    PfFAS-II inhibitor 1
    		Inhibitor
    PfFAS-II inhibitor 1 (Compound 3) is a Plasmodium falciparum type II fatty acid biosynthesis pathway (PfFAS-II) inhibitor, with an IC50 of 0.63 μM for PfFabI enzyme. PfFAS-II inhibitor 1 has antimalarial activity.
    PfFAS-II inhibitor 1
  • HY-P3425A
    AGPV TFA
    		Inhibitor
    AGPV TFA, a tetrapeptide, has the potential for prevention of schistosome parasite infection research.
    AGPV TFA
  • HY-N16542
    n-Butylorsellinate
    		Inhibitor
    N-Butylorsellinate is a butyl thicoline acid ester that can be found in fungi belonging to the Stereum genus. N-Butylorsellinate exhibits significant larvicide activity.
    n-Butylorsellinate
  • HY-112252
    MDL 73811
    		Inhibitor
    MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT.
    MDL 73811
  • HY-Y0152A
    Cinchonine monohydrochloride hydrate
    		Inhibitor
    Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis.
    Cinchonine monohydrochloride hydrate
  • HY-18719ER
    Endoxifen (Standard)
    		Inhibitor
    Methicillin (sodium hydrate) (Standard) is the analytical standard of Methicillin (sodium hydrate). This product is intended for research and analytical applications. Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis.
    Endoxifen (Standard)
  • HY-141837
    MMV674850
    		Inhibitor
    MMV674850 is potent against asexual stage parasites at 2.7 and 4.5 nM and preferentially targets early-stage gametocytes (early-stage gametocyte: IC50 4.5 ± 3.6 nM; late-stage gametocyte: IC50 28.7 ± 0.2 nM).
    MMV674850
  • HY-159080
    HgCht2-IN-1
    HgCht2-IN-1 (compound 1516b) is a HgCht2 inhibitor that successfully inhibits the antagonism of cyst nematodes against nitrogen-fixing rhizobia and phosphate-absorbing arbuscular mycorrhizal symbionts. HgCht2-IN-1 can be used in the study of cyst nematode antagonism against microbial symbionts.
    HgCht2-IN-1
  • HY-163457
    Antileishmanial agent-27
    		Inhibitor
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties.
    Antileishmanial agent-27
  • HY-146071
    Antitrypanosomal agent 5
    		Inhibitor
    Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC50s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively.
    Antitrypanosomal agent 5
  • HY-21191S
    Perfluorobutanesulfonic acid-13C3 sodium
    Perfluorobutanesulfonic acid-13C3 (PFBS-13C3) sodium is the 13C-labeled Perfluorobutanesulfonic acid (HY-21191). Perfluorobutanesulfonic acid is a surfactant that can disrupt the development of pancreatic organs and lipid metabolism regulation in zebrafish. Perfluorobutanesulfonic acid can harm the reproductive ability of nematodes (Caenorhabditis elegans) and alter the physiological functions of their offspring.
    Perfluorobutanesulfonic acid-<sup>13</sup>C<sub>3</sub> sodium
  • HY-B1072R
    Phenothrin (Standard)
    		Inhibitor
    Phenothrin (Standard) is the analytical standard of Phenothrin (HY-B1072). This product is intended for research and analytical applications. Phenothrin is a Type I pyrethroid insecticide. Phenothrin induces dose-dependent DNA damage in human peripheral blood lymphocytes and hepatocytes, and exhibits definite genotoxic potential. Phenothrin acts as an insecticide for pest control in agriculture, households and public health, as well as for the elimination of human head lice infestations.
    Phenothrin (Standard)
  • HY-149985
    Antitrypanosomal agent 12
    		Inhibitor
    Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI50) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597).
    Antitrypanosomal agent 12
Parasite Isoform Comparison

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